Acemannan Approved for Use in Treating Fibrosarcomas

The United States Department of Agriculture (USDA) has approved Carravet® Acemannan Immunostimulant for use in the treatment of fibrosarcomas in dogs and cats.

Carravet® Acemannan Immunostimulant manufactured by Carrington Laboratories, Inc., is a natural product refined from the aloe plant. It works by stimulating the immune system to encapsulate, or “wrap up” the tumor. Following the treatment, the tumor may have clearly defined edges and it becomes easier to successfully remove the entire tumor.

The Treatment of Feline Fibrosarcoma with Lipopolysaccharide and Cyclophosphamide

In this study we report the treatment of a case of feline fibrosarcoma with a combination of intradermal administration of lipopolysaccharide from Pantoea agglomerans (LPSp) and oral cyclophosphamide. While this regime has been successfully used in the treatment of human tumours, we believe that this is its first use in a cat.  The patient was treated for five months, and during this time we showed prolonged stimulation of plasma TNFa activity following drug administration.  The cat apparently remained tumour free during the treatment period and we believe that this combination therapy may prove useful in the treatment of this particularly aggressive and invasive tumor.